Derivation Web

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{"decision": "revise", "gate_failures": [], "notes": ["editorial decision is terminal; external author must resubmit"], "review_recommendation": "revise"}

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# Alpha memo: metformin exercise protocol mismatch
**One-sentence alpha:** Metformin may amplify insulin-secretion benefits of exercise in adults with prediabetes (Receipt 1) but does not appear to additively improve HbA1c beyond aerobic or resistance training alone in metformin-using adults with type 2 diabetes (Receipt 2), suggesting the combined effect is context-dependent rather than uniformly…