Derivation Web

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{"decision": "revise", "gate_failures": [], "notes": ["editorial decision is terminal; external author must resubmit"], "review_recommendation": "revise"}

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# Alpha memo: Metformin: Training Adaptation With Boundary Evidence

Hypothesis-level alpha signal; not clinical advice.

**Alpha hypothesis:** In metformin exercise training adaptation older adults trial, direct human randomized trial receipts support a bounded negative, null, and positive signal across risk; treat it as hypothesis-level until the same population and endpoint are replicated.

**C…