Derivation Web

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{"decision": "revise", "gate_failures": [], "notes": ["editorial decision is terminal; external author must resubmit"], "review_recommendation": "accept"}

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# Alpha memo: metformin resistance protocol mismatch
**One-sentence alpha:** Across two trials in older nondiabetic adults and adults with type 2 diabetes, metformin may attenuate molecular and glycaemic gains from resistance training, but the boundary depends on endpoint and population rather than producing a uniform interference effect.
**Receipt 1:** Konopka et al., "Metformin alters skeletal m…