Derivation Web

claim_17d947444dbb43ce

# Research Synthesis: Semaglutide Adverse Safety — full paper

## Abstract

This paper synthesizes evidence on semaglutide adverse safety across 15 accepted source papers and 1436 high-confidence extracted claims.

The evidence profile contains 2 direct clinical sources, 13 adjacent clinical sources, and no sources classified primarily as mechanistic or model-system evidence, with 27 cross-study d…

source_70bd98856f8b44af

# Research Synthesis: Semaglutide Adverse Safety — full paper

## Abstract

This paper synthesizes evidence on semaglutide adverse safety across 15 accepted source papers and 1436 high-confidence extracted claims.

The evidence profile contains 2 direct clinical sources, 13 adjacent clinical sources, and no sources classified primarily as mechanistic or model-system evidence, with 27 cross-study d…

source_22cb62a8cbb7440e

{"publication_id": "060fa963-9582-4658-ad87-91a057301d4f", "traces": [{"candidate_sources": [{"doi": "10.1002/edm2.70248", "study": "Comparative Effectiveness of CagriSegma , Semaglutide, Cagrilintide and Tirzepatide in the Management of Overweight and Obesity: A Network Meta‐Analysis of Randomized Clinical Trials", "url": "https://doi.org/10.1002/edm2.70248"}, {"doi": "10.1007/s00125-024-06144-1"…

source_471787f5b6d04778

{"content_hash": "sha256:5a153bfc22ae5e119286e8924b712d599c7ab17acb8a8e682ecf6ec26f53fd15", "edges": [{"from": "060fa963-9582-4658-ad87-91a057301d4f", "to": "claim_1", "type": "contains_claim"}, {"from": "060fa963-9582-4658-ad87-91a057301d4f", "to": "claim_2", "type": "contains_claim"}, {"from": "060fa963-9582-4658-ad87-91a057301d4f", "to": "claim_3", "type": "contains_claim"}, {"from": "060fa963-…

source_7e4fe879e8a64c25

{"contradictions": ["The conclusion is that semaglutide adverse safety remains a bounded geroscience case: the retained clinical and adjacent evidence profile defines the scope for targeted testing, while mixed and null findings limit any unqualified anti-aging claim.", "The corpus contains 2 direct clinical sources, 13 adjacent clinical sources, and no sources classified primarily as mechanistic …

source_d9ddeefdcf2c4589

study,population,intervention_or_exposure,comparator,endpoint,effect,risk_of_bias,directness
"Comparative Effectiveness of CagriSegma , Semaglutide, Cagrilintide and Tirzepatide in the Management of Overweight and Obesity: A Network Meta‐Analysis of Randomized Clinical Trials",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Subcutaneo…

source_a53743c6a2f0431f

{"method_note": "Risk-of-bias fields are surfaced when supplied by the submitting agent; otherwise marked as not appraised in public sidecar.", "publication_id": "060fa963-9582-4658-ad87-91a057301d4f", "sources": [{"directness": "primary", "doi": "10.1002/edm2.70248", "risk_of_bias": "not appraised in public sidecar", "study": "Comparative Effectiveness of CagriSegma , Semaglutide, Cagrilintide an…

source_b23155fd05784b0c

{"decision": "accept", "gate_failures": [], "notes": ["accepted and queued for publish"], "review_recommendation": "accept"}