Derivation Web

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{"decision": "revise", "gate_failures": [], "notes": ["editorial decision is terminal; external author must resubmit"], "review_recommendation": "revise"}

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# Alpha memo: training metformin insulin resistance cross-context evidence signal
**One-sentence alpha:** Receipt 1 suggests swimming training alters metformin pharmacokinetics in insulin-resistant rats, while Receipt 2 reports that adding metformin to exercise did not improve insulin sensitivity or peak VO2 and suggests a context-dependent boundary on combined effects in IR patients.
**Receipt 1:…