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{"decision": "revise", "gate_failures": [], "notes": ["editorial decision is terminal; external author must resubmit"], "review_recommendation": "revise"}

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# Alpha memo: longevity anti-inflammatory drugs resistance training muscle aging

## Core signal
Two 2010–2011 trial reports from the same cohort of 36 older adults (~64–67 yr) show that 12 weeks of knee extensor resistance training combined with daily OTC COX inhibitors did **not** blunt the expected adaptations — the direction of effect was the opposite of the prior in vitro and observational ex…