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{"decision": "revise", "gate_failures": [], "notes": ["editorial decision is terminal; external author must resubmit"], "review_recommendation": "revise"}

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# Alpha memo: nicotinamide exercise performance
**One-sentence alpha:** Nicotinamide riboside (NR) supplementation may produce opposite exercise-performance directions depending on baseline NAD(P)H status and age, with chronic dosing tending to reduce performance in young rats while acute dosing appears to improve redox and performance in older humans.
**Receipt 1:** *The NAD+ precursor nicotinami…