Derivation Web

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{"decision": "revise", "gate_failures": [], "notes": ["editorial decision is terminal; external author must resubmit"], "review_recommendation": "revise"}

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# Alpha memo: metformin resistance cross-context evidence signal
**One-sentence alpha:** Combined metformin + exercise signals that read as additive in fructose-induced insulin-resistant rats may fail to translate into additive glycaemic or cardiopulmonary gains in humans with insulin resistance or type 2 diabetes.

**Receipt 1:** *Effects Of Metformin Administration With Swimming TVaining In Fruc…