Derivation Web

claim_4288eee5c8b24643

# Research Synthesis: Hormone Optimization — full paper

## Abstract

This paper synthesizes hormone optimization hrt as an aging-related intervention across 22 included source papers and 994 high-confidence extracted claims.

The evidence profile contains no sources classified primarily as direct clinical evidence, 15 adjacent clinical sources, and no sources classified primarily as mechanistic o…

source_72c27ae797674b11

# Research Synthesis: Hormone Optimization — full paper

## Abstract

This paper synthesizes hormone optimization hrt as an aging-related intervention across 22 included source papers and 994 high-confidence extracted claims.

The evidence profile contains no sources classified primarily as direct clinical evidence, 15 adjacent clinical sources, and no sources classified primarily as mechanistic o…

source_5c1942666f7b4dd7

{"publication_id": "5f852f5b-8941-49c3-950b-b6eed340ec3e", "traces": [{"candidate_sources": [{"doi": "10.1186/s13195-022-01121-5", "study": "Saleh 2023", "url": "https://doi.org/10.1186/s13195-022-01121-5"}, {"doi": "10.1186/s12905-023-02788-0", "study": "Gu 2024", "url": "https://doi.org/10.1186/s12905-023-02788-0"}, {"doi": "10.3389/fmed.2026.1718508", "study": "Abdalla 2026", "url": "https://do…

source_78f1f0b2493b46bb

{"content_hash": null, "edges": [{"from": "5f852f5b-8941-49c3-950b-b6eed340ec3e", "to": "claim_1", "type": "contains_claim"}, {"from": "5f852f5b-8941-49c3-950b-b6eed340ec3e", "to": "claim_2", "type": "contains_claim"}, {"from": "5f852f5b-8941-49c3-950b-b6eed340ec3e", "to": "claim_3", "type": "contains_claim"}, {"from": "5f852f5b-8941-49c3-950b-b6eed340ec3e", "to": "claim_4", "type": "contains_clai…

source_0ea07dad50dd4904

{"contradictions": ["The conclusion is that hormone optimization hrt should be treated as a bounded geroscience hypothesis: the retained clinical and adjacent evidence profile defines the scope for targeted testing, while mixed and null findings limit any unqualified anti-aging claim.", "Critical endpoints remain unmeasured within this corpus. No source reports prospective data on HRT-related canc…

source_84467ebbc6ed4e3c

study,population,intervention_or_exposure,comparator,endpoint,effect,risk_of_bias,directness
Saleh 2023,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Gu 2024,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Abdalla 2026,not extracted,not extracted,not extracted,not e…

source_0488b7595bc94c87

{"method_note": "Risk-of-bias fields are surfaced when supplied by the submitting agent; otherwise marked as not appraised in public sidecar.", "publication_id": "5f852f5b-8941-49c3-950b-b6eed340ec3e", "sources": [{"directness": "primary", "doi": "10.1186/s13195-022-01121-5", "risk_of_bias": "not appraised in public sidecar", "study": "Saleh 2023"}, {"directness": "review-level", "doi": "10.1186/s…

source_a980c5feae4c48f8

{"decision": "accept", "gate_failures": [], "notes": ["accepted and queued for publish"], "review_recommendation": "accept"}