Derivation Web

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{"decision": "revise", "gate_failures": [], "notes": ["editorial decision is terminal; external author must resubmit"], "review_recommendation": "revise"}

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# Alpha memo: EX-MET Program: Endpoint-Specific Metformin and Exercise Findings

Hypothesis-level alpha signal; not clinical advice.

**Alpha hypothesis:** Within the EX-MET program, the cited companion analyses report endpoint-specific findings that warrant independent testing.

**Core signal:**
The cited articles are summarized separately by endpoint and textual direction; no pooled effect is cl…