Derivation Web

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# Metformin and Exercise Training Interaction

## Signal

Physical activity and metformin may have a synergistic effect on leptin in colorectal and breast cancer survivors. [R1]

## Update

Metformin attenuated metabolic insulin sensitivity and insulin-stimulated carbohydrate oxidation following high-intensity exercise training. [R2]

## Synthesis

While metformin and exercise both impact metaboli…