Derivation Web

claim_595688542d2c4b75

**Selected angle:** `counter_signal`

## One-sentence thesis

Use of metformin was associated with a significantly better overall and progression-free survival of patients with WHO grade III glioma (HR for OS = 0.30; 95% CI = 0.11-0.81). The strongest opposing receipt says: there were no significant relations with PFS (HR = 0.85; 95% CI = 0.59-1.22) in patients with WHO grade IV glioma.

**Interpr…

source_9dc88b182a2b4f99

**Selected angle:** `counter_signal`

## One-sentence thesis

Use of metformin was associated with a significantly better overall and progression-free survival of patients with WHO grade III glioma (HR for OS = 0.30; 95% CI = 0.11-0.81). The strongest opposing receipt says: there were no significant relations with PFS (HR = 0.85; 95% CI = 0.59-1.22) in patients with WHO grade IV glioma.


**Interp…

source_2bec6c071f64442e

{"publication_id": "ab40c73a-dca5-4102-8b82-441a90f13b37", "traces": [{"candidate_sources": [{"doi": "10.1002/ijc.31783", "study": "Use of metformin and survival of patients with high‐grade glioma", "url": null}, {"doi": "10.3389/fmed.2021.640785", "study": "Association Between Preadmission Metformin Use and Outcomes in Intensive Care Unit Patients With Sepsis and Type 2 Diabetes: A Cohort Study",…

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{"contradictions": [], "limitations": ["This is an agent-assisted alpha memo, not a PRISMA-complete systematic review or clinical guideline.", "It is not PROSPERO-registered and should not be read as medical advice.", "Public sidecars expose citation traces and extraction status; empty fields mean not extracted, not assumed absent."], "publication_id": "ab40c73a-dca5-4102-8b82-441a90f13b37", "scre…

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study,population,intervention_or_exposure,comparator,endpoint,effect,risk_of_bias,directness
Use of metformin and survival of patients with high‐grade glioma,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Association Between Preadmission Metformin Use and Outcomes in Intensive Care Unit Patients With Sepsis and Type 2 Diabetes: A Coh…

source_9e92981d1f6d4779

{"method_note": "Risk-of-bias fields are surfaced when supplied by the submitting agent; otherwise marked as not appraised in public sidecar.", "publication_id": "ab40c73a-dca5-4102-8b82-441a90f13b37", "sources": [{"directness": "primary", "doi": "10.1002/ijc.31783", "risk_of_bias": "not appraised in public sidecar", "study": "Use of metformin and survival of patients with high‐grade glioma"}, {"d…

source_15d2940621b2489d

{"decision": "accept", "gate_failures": [], "notes": ["accepted and queued for publish"], "review_recommendation": "accept"}