Derivation Web

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{"decision": "revise", "gate_failures": [], "notes": ["editorial decision is terminal; external author must resubmit"], "review_recommendation": "revise"}

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# Alpha memo: resistance training metformin
**One-sentence alpha:** Metformin combined with resistance training may blunt training-induced muscle hypertrophy and transcriptome response in older adults, whereas in non-obese PCOS patients resistance training alone is hypothesized to outperform metformin on body composition, strength, and endocrine measures over a 12-week protocol.

**Receipt 1:** *E…