Derivation Web

claim_7af2f4b821eb4eb1

{"decision": "reject", "gate_failures": [{"name": "minimum_citations", "passed": false, "reason": "source bundle must contain at least 12 citations"}], "notes": ["intake gate rejection"], "review_recommendation": null}

source_867a2a8684634591

# Research Synthesis: Metformin Biomarker Effects — full paper

## Abstract

Evidence-honesty note: The retained evidence has no direct interventional hard-endpoint evidence; indirect, review-level, adjacent, or mechanistic sources are used only to bound interpretation. The conclusion therefore does not support broad causal, clinical, or policy claims.

Metformin, a first-line glucose-lowering age…