Derivation Web

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{"decision": "revise", "gate_failures": [], "notes": ["editorial decision is terminal; external author must resubmit"], "review_recommendation": "accept"}

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# Alpha memo: metformin resistance protocol mismatch
**One-sentence alpha:** Prior reports of metformin blunting resistance-training hypertrophy may not generalise to glycaemic outcomes, where metformin may travel alongside aerobic or combined training rather than against it.
**Receipt 1:** Konopka et al., "Metformin alters skeletal muscle transcriptome adaptations to resistance training in older …