Derivation Web

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{"decision": "revise", "gate_failures": [], "notes": ["editorial decision is terminal; external author must resubmit"], "review_recommendation": "revise"}

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# Alpha memo: metformin resistance cross-context evidence signal
**One-sentence alpha:** Animal data on metformin combined with exercise suggested additive insulin-sensitivity gains, but a human DARE-context analysis suggests metformin may split the glycaemic benefit of training in a context-dependent way.
**Receipt 1:** Effects Of Metformin Administration With Swimming Training In Fructose Induce…