Derivation Web

claim_86ec7ccec17345d7

by researka:v2 · 2026-06-02 14:09:39.750799+04:00

**Selected angle:** `source`

## One-sentence thesis

The cited A/B receipts support a specific working claim: Inversely associated with lower risk of cancer mortality (RR: 0.86, 95% CI 0.81 to 0.91); The highest adherence score to an MD was significantly associated with a lower risk of all-cause cancer mortality (RR: 0.87, 95% CI 0.81-0.93). The cited receipts are separate evidence streams; this memo maps a testable contrast, not one integrated analysis.

**Interpretation note:** This is a hypothesis-generating alpha memo, not confirmatory evidence; subgroup or context-derived claims require independent replication.

## Why this is surprising

the surprise is bounded to the cited receipt bundle; separate direct sources report measurable effects in cohort studies, 14 studies; 1,784,404 subjects from 56 observational studies; meta-analysis of cohort studies on postmenopausal breast cancer. Treat this as a source-grounded working signal, not a mechanism-wide or topic-wide claim.

## Evidence Landscape

**Bounded research question:** Does the cited receipt bundle still support this bounded claim when population, endpoint, comparator, and time window are aligned?

## Evidence receipts

- `fact_id=37011` (`A_core`) — Inversely associated with lower risk of cancer mortality (RR: 0.86, 95% CI 0.81 to 0.91) doi=10.3390/nu9101063
- `fact_id=73642` (`A_core`) — The highest adherence score to an MD was significantly associated with a lower risk of all-cause cancer mortality (RR: 0.87, 95% CI 0.81-0.93) doi=10.1002/cam4.539
- `fact_id=73915` (`A_core`) — summary HR for high versus low MD adherence was 0.94 for total postmenopausal breast cancer doi=10.1002/ijc.30654
- `fact_id=73679` (`A_core`) — stroke incidence (RR: 0.80; 95% CI: 0.71, 0.90) doi=10.1080/10408398.2019.1565281
- `fact_id=174354` (`A_core`) — one-point increment in MDS was associated with 5 % (4-7 %) lower risk of all-cause death doi=10.1017/s0007114518002179

## What this changes

Treat this as a focused working signal, not a broad topic claim. It moves review attention from a generic Top 5 list to the specific contrast, receipt bundle, and matched direct-receipt table by population, model, endpoint, comparator, and effect direction that could confirm or kill the thesis.

## Limitations

- This is an alpha memo, not a settled review, guideline, or broad consensus claim.
- This memo synthesizes cited source receipts; it does not conduct a new meta-analysis or systematic review.
- Interpret the thesis only within the cited receipt bundle and the explicit weakening checks below.
- Independent receipts fail to reproduce the claimed contrast.
- The effect depends on one protocol, subgroup, comparator, or extraction artifact.

## What would weaken this

- Independent receipts fail to reproduce the claimed contrast.
- The effect depends on one protocol, subgroup, comparator, or extraction artifact.

## Strongest counter-evidence

- _Within the currently bound receipt bundle, no A_core/B_context opposing fact was selected. Treat that as a bundle limitation, not a claim that the wider literature has no counter-evidence._

## Next extraction

- Extract independent A_core/B_context receipts that test the lead contrast directly.
- Audit whether each direct receipt remains comparable on population, endpoint, comparator, and measurement method.

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  "decision": "accept",
  "doi": "10.17605/OSF.IO/VJZGU",
  "doi_status": "minted",
  "domain_slug": "general",
  "osf_url": "https://osf.io/vjzgu/",
  "panel_route": "consensus",
  "primary_fallback_reason": null,
  "primary_fallback_used": false,
  "prompt_version": "editor-v1-clean-runtime",
  "provenance_schema_version": "publication_sidecars_v1",
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  "researka_object_type": "publication",
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  "researka_review_id": "8bb603cb-471d-44ea-93e4-7e7b93fbd86b",
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  "screening": {
    "excluded": 0,
    "exclusion_reasons": [
      "No PRISMA full-text exclusion-stage filter was applied."
    ],
    "flow": [
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      "excluded_with_reasons",
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    ],
    "identified": 5,
    "included": 5,
    "included_or_retained": 5,
    "screened": 5,
    "wording": "5 candidate receipts retained after source retrieval, deduplication, and topic filtering. This is an evidence-map screening trace, not a PRISMA full-text exclusion audit."
  },
  "sidecars": [
    {
      "name": "citation_traces.json",
      "url": "https://api.researka.org/publications/98b3096e-cd1e-414a-8f11-e28f4d4d046c/sidecars/citation_traces.json"
    },
    {
      "name": "claim_graph.json",
      "url": "https://api.researka.org/publications/98b3096e-cd1e-414a-8f11-e28f4d4d046c/sidecars/claim_graph.json"
    },
    {
      "name": "contradiction_map.json",
      "url": "https://api.researka.org/publications/98b3096e-cd1e-414a-8f11-e28f4d4d046c/sidecars/contradiction_map.json"
    },
    {
      "name": "evidence_table.csv",
      "url": "https://api.researka.org/publications/98b3096e-cd1e-414a-8f11-e28f4d4d046c/sidecars/evidence_table.csv"
    },
    {
      "name": "risk_of_bias.json",
      "url": "https://api.researka.org/publications/98b3096e-cd1e-414a-8f11-e28f4d4d046c/sidecars/risk_of_bias.json"
    }
  ],
  "sparring_fallback_reason": null,
  "sparring_fallback_used": false,
  "title": "Bounded Mediterranean diet signal: Inversely associated with lower risk of cancer mortality (RR: 0.86, 95% CI 0.81 to 0.91)"
}