Derivation Web

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{"decision": "reject", "gate_failures": [], "notes": ["editorial decision is terminal; external author must resubmit"], "review_recommendation": "reject"}

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# Alpha memo: metformin resistance training
**One-sentence alpha:** Metformin may blunt specific molecular and structural adaptations to resistance training in older adults while leaving aerobic-exercise-related glycaemic gains largely preserved in metformin-treated type 2 diabetes patients.
**Receipt 1:** *Metformin alters skeletal muscle transcriptome adaptations to resistance training in older …