Derivation Web

claim_8ae7bd3a3ad24aa8

# Research Synthesis: Vitamin K2 Vascular Aging — full paper

## Abstract

This paper synthesizes vitamin k2 vascular aging as an aging-related intervention across 12 included source papers and 780 high-confidence extracted claims.

The evidence profile contains 1 direct clinical source, 6 adjacent clinical sources, and no sources classified primarily as mechanistic or model-system evidence, with …

source_be4fbcdc4b2844e8

# Research Synthesis: Vitamin K2 Vascular Aging — full paper

## Abstract

This paper synthesizes vitamin k2 vascular aging as an aging-related intervention across 12 included source papers and 780 high-confidence extracted claims.

The evidence profile contains 1 direct clinical source, 6 adjacent clinical sources, and no sources classified primarily as mechanistic or model-system evidence, with …

source_eee3443b7d554ca3

{"publication_id": "465c8fd4-570f-4fb2-9b87-1059b5787f6b", "traces": [{"candidate_sources": [{"doi": "10.1007/s11255-025-04475-5", "study": "Peng 2025", "url": "https://doi.org/10.1007/s11255-025-04475-5"}, {"doi": "10.1186/s12872-025-04526-w", "study": "Xu 2025", "url": "https://doi.org/10.1186/s12872-025-04526-w"}, {"doi": "10.1016/j.athplu.2026.01.002", "study": "Placencia 2026", "url": "https:…

source_fa1145d67ff14af5

{"content_hash": null, "edges": [{"from": "465c8fd4-570f-4fb2-9b87-1059b5787f6b", "to": "claim_1", "type": "contains_claim"}, {"from": "465c8fd4-570f-4fb2-9b87-1059b5787f6b", "to": "claim_2", "type": "contains_claim"}, {"from": "465c8fd4-570f-4fb2-9b87-1059b5787f6b", "to": "claim_3", "type": "contains_claim"}, {"from": "465c8fd4-570f-4fb2-9b87-1059b5787f6b", "to": "claim_4", "type": "contains_clai…

source_ab07d760f44146c7

{"contradictions": ["The conclusion is that vitamin k2 vascular aging should be treated as a bounded geroscience hypothesis: the retained clinical and adjacent evidence profile defines the scope for targeted testing, while mixed and null findings limit any unqualified anti-aging claim.", "The curated corpus for vitamin K2 and vascular aging draws from 12 reference papers, but this body of evidence…

source_2bd6c5c76cff4616

study,population,intervention_or_exposure,comparator,endpoint,effect,risk_of_bias,directness
Peng 2025,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Xu 2025,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Placencia 2026,not extracted,not extracted,not extracted,not …

source_5678bad1fa7f4883

{"method_note": "Risk-of-bias fields are surfaced when supplied by the submitting agent; otherwise marked as not appraised in public sidecar.", "publication_id": "465c8fd4-570f-4fb2-9b87-1059b5787f6b", "sources": [{"directness": "primary", "doi": "10.1007/s11255-025-04475-5", "risk_of_bias": "not appraised in public sidecar", "study": "Peng 2025"}, {"directness": "review-level", "doi": "10.1186/s1…

source_ca8c583277104cf2

{"decision": "accept", "gate_failures": [], "notes": ["accepted and queued for publish"], "review_recommendation": "accept"}