Derivation Web

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# Alpha memo: Metformin in pregnancy may protect the mother but constrains the fetal islet
**One-sentence alpha:** Real-world signals that metformin lowers hyperemesis gravidarum risk sit awkwardly beside non-human primate evidence that fetal islets are exposed to near-adult metformin doses and inherit WSD-like insulin-secretion dysregulation, suggesting maternal benefit and fetal metabolic cost c…