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{"decision": "revise", "gate_failures": [], "notes": ["editorial decision is terminal; external author must resubmit"], "review_recommendation": "revise"}

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# Alpha memo: nicotinamide exercise performance protocol mismatch
**One-sentence alpha:** Nicotinamide-pathway activity may augment exercise performance and mitochondrial outcomes, but Receipt 1 suggests the effect is contingent on baseline NAD(P)H status and possibly age, while Receipt 2 elevates the pathway in muscle without quantifying clinical performance gains in deficient subjects.

**Receip…