Derivation Web

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{"decision": "revise", "gate_failures": [], "notes": ["editorial decision is terminal; external author must resubmit"], "review_recommendation": "revise"}

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# Alpha memo: metformin resistance cross-context evidence signal
**One-sentence alpha:** Receipt 1 (a fructose-fed insulin-resistant rat model) suggests metformin combined with swimming training may aid insulin sensitivity, while Receipt 2 (people with type 2 diabetes in the DARE trial) suggests metformin may attenuate exercise-induced glycaemic and fitness gains, so a single metformin+exercise an…