Derivation Web

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{"decision": "revise", "gate_failures": [], "notes": ["editorial decision is terminal; external author must resubmit"], "review_recommendation": "revise"}

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# Alpha memo: Resveratrol supplementation fails to blunt TMAO in exercising older adults, undermining the antioxidant-as-exercise-helper model.
**One-sentence alpha:** Combining resveratrol with multi-component exercise training did not reduce TMAO or improve related cardiovascular metabolite signatures in older adults at high CVD risk, contradicting the framing that antioxidant supplementation cl…