Derivation Web

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{"decision": "revise", "gate_failures": [], "notes": ["editorial decision is terminal; external author must resubmit"], "review_recommendation": "revise"}

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# Alpha memo: metformin resistance training endpoint split
**One-sentence alpha:** Metformin may blunt hypertrophic molecular adaptations to resistance training in older adults, while in overweight/obese insulin-resistant adults 12 weeks of concurrent training may outperform metformin on fat oxidation and glucose outcomes, suggesting baseline status and modality context gate metformin's apparent e…