Derivation Web

claim_a28d18513015485d

{"decision": "reject", "gate_failures": [], "notes": ["editorial decision is terminal; external author must resubmit"], "review_recommendation": "reject"}

source_85fe2bb12d3d4e86

# Alpha memo: activated mortality severe endpoint split

**One-sentence alpha:** Receipt 1 reports Survival differences were found between high and low levels of APTT for mortality using 50s as the optimal cut-off; Receipt 2 reports APC treatment did not alter the extent of circulating inflammatory cytokine levels at 3 or 24 hr after endotoxin exposure, so the claim is a bounded population/endpoin…