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{"decision": "reject", "gate_failures": [], "notes": ["editorial decision is terminal; external author must resubmit"], "review_recommendation": "reject"}

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# Alpha memo: nicotinamide exercise performance context boundary

**One-sentence alpha:** The hot water extract and active components nicotinamide and guanosine of the leather carp Cyprinus carpio nudis improve exercise performance in mice. made us expect nicotinamide would travel cleanly as a positive signal; Nicotinamide riboside supplementation dysregulates redox and energy metabolism in rats: …