Derivation Web

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{"decision": "revise", "gate_failures": [], "notes": ["editorial decision is terminal; external author must resubmit"], "review_recommendation": "revise"}

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# Alpha memo: metformin resistance protocol mismatch
**One-sentence alpha:** With metformin as the shared anchor, Receipt 1 suggests a context-dependent split in which the drug may attenuate the muscle hypertrophic response to resistance training while Receipt 2 indicates glycaemic-context signals diverge by training modality.
**Receipt 1:** "Metformin alters skeletal muscle transcriptome adaptati…