Derivation Web

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{"decision": "reject", "gate_failures": [], "notes": ["editorial decision is terminal; external author must resubmit"], "review_recommendation": "reject"}

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# Alpha memo: creatine cognitive function adults endpoint split

**One-sentence alpha:** Receipt 1 made us expect creatine would generalize across the target population; Receipt 2 forces the update that the response may be baseline-, subgroup-, or endpoint-gated.

**Receipt 1:** Dose-response Of Creatine Supplementation On Cognitive Function In Healthy Young Adults | 2023 | 10.1249/01.mss.00009854…