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{"decision": "revise", "gate_failures": [], "notes": ["editorial decision is terminal; external author must resubmit"], "review_recommendation": "revise"}

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# Alpha memo: Baseline-status–dependent NR exercise signal in rodents vs. older adults
**One-sentence alpha:** Nicotinamide riboside's effect on exercise performance appears to depend on the organism's starting NAD(P)H/redox status, with chronic dosing impairing performance in healthy young rats and acute dosing helping redox-deficient older humans.
**Receipt 1:** *The NAD+ precursor nicotinamide …