Derivation Web

claim_be34d62a80a6479a

# Hypothesis-Generating Brief: Creatine monohydrate — full paper

## Abstract

This paper synthesizes evidence on Creatine monohydrate across 28 accepted source papers and 1882 high-confidence extracted claims.

The evidence profile contains 4 direct clinical sources, 23 adjacent clinical sources, and 1 mechanistic or model-system source, with a high-density pairwise disagreement map across the ev…

source_fa989568ec284887

# Hypothesis-Generating Brief: Creatine monohydrate — full paper

## Abstract

This paper synthesizes evidence on Creatine monohydrate across 28 accepted source papers and 1882 high-confidence extracted claims.

The evidence profile contains 4 direct clinical sources, 23 adjacent clinical sources, and 1 mechanistic or model-system source, with a high-density pairwise disagreement map across the ev…

source_87a7d79580b24ec2

{"publication_id": "20c54f16-9fa0-483f-a812-d305b4b1d813", "traces": [{"candidate_sources": [{"doi": "10.1007/s40279-022-01640-z", "study": "The Paradoxical Effect of Creatine Monohydrate on Muscle Damage Markers: A Systematic Review and Meta-Analysis", "url": "https://doi.org/10.1007/s40279-022-01640-z"}, {"doi": "10.1186/s11556-025-00392-9", "study": "The impact of creatine supplementation assoc…

source_875e8f51b2174aa6

{"content_hash": "sha256:e3eee1fc2c04bd88ecc07ca379816e491d5e330518c145e01dd02c55d36bdd1e", "edges": [{"from": "20c54f16-9fa0-483f-a812-d305b4b1d813", "to": "claim_1", "type": "contains_claim"}, {"from": "20c54f16-9fa0-483f-a812-d305b4b1d813", "to": "claim_2", "type": "contains_claim"}, {"from": "20c54f16-9fa0-483f-a812-d305b4b1d813", "to": "claim_3", "type": "contains_claim"}, {"from": "20c54f16-…

source_ed0b69bed1f94f53

{"contradictions": ["The conclusion is that Creatine monohydrate remains a bounded geroscience case: the retained clinical and mechanistic evidence profile defines the scope for targeted testing, while mixed and null findings limit any unqualified anti-aging claim.", "Creatine is a guanidino compound endogenously synthesized from arginine, glycine, and methionine, and it is consumed in the diet in…

source_14499d66c303470f

study,population,intervention_or_exposure,comparator,endpoint,effect,risk_of_bias,directness
The Paradoxical Effect of Creatine Monohydrate on Muscle Damage Markers: A Systematic Review and Meta-Analysis,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
The impact of creatine supplementation associated with resistance training on m…

source_76f031b92f394fa6

{"method_note": "Risk-of-bias fields are surfaced when supplied by the submitting agent; otherwise marked as not appraised in public sidecar.", "publication_id": "20c54f16-9fa0-483f-a812-d305b4b1d813", "sources": [{"directness": "review-level", "doi": "10.1007/s40279-022-01640-z", "risk_of_bias": "not appraised in public sidecar", "study": "The Paradoxical Effect of Creatine Monohydrate on Muscle …

source_a0b6cc4d94b34936

{"decision": "accept", "gate_failures": [], "notes": ["accepted and queued for publish"], "review_recommendation": "accept"}