Derivation Web

claim_c098c78bc6df4769

**Selected angle:** `boundary_condition`

## One-sentence thesis

longer LTL was associated with higher brain volume (β = 0.43, 95%CI: 0.36-0.50%, p = 0.008, N = 1102). Boundary receipts add a second constraint: In PANTHER-IPF, exposure to prednisone/azathioprine/N-acetylcysteine was associated with a higher composite endpoint for those with an LTL less than the 10th percentile (hazard ratio, 2.84…

source_a9cb4a7d98914d49

**Selected angle:** `boundary_condition`

## One-sentence thesis

longer LTL was associated with higher brain volume (β = 0.43, 95%CI: 0.36-0.50%, p = 0.008, N = 1102). Boundary receipts add a second constraint: In PANTHER-IPF, exposure to prednisone/azathioprine/N-acetylcysteine was associated with a higher composite endpoint for those with an LTL less than the 10th percentile (hazard ratio, 2.84…

source_48851c69dd5348da

{"publication_id": "f271139f-9010-4c8e-bab9-67019d5a231a", "traces": [{"candidate_sources": [{"doi": "10.1016/j.arr.2022.101679", "study": "Telomere length and brain aging: A systematic review and meta-analysis", "url": null}, {"doi": "10.1016/j.arr.2018.09.002", "study": "Telomere Length and All-Cause Mortality: A Meta-analysis", "url": null}, {"doi": "10.1111/acel.13017", "study": "Telomere leng…

source_6a7535bcb1484450

{"content_hash": null, "edges": [{"from": "f271139f-9010-4c8e-bab9-67019d5a231a", "to": "claim_1", "type": "contains_claim"}, {"from": "f271139f-9010-4c8e-bab9-67019d5a231a", "to": "claim_2", "type": "contains_claim"}, {"from": "f271139f-9010-4c8e-bab9-67019d5a231a", "to": "claim_3", "type": "contains_claim"}, {"from": "f271139f-9010-4c8e-bab9-67019d5a231a", "to": "claim_4", "type": "contains_clai…

source_0716cd83de92420d

{"contradictions": ["Real tension: the interesting signal is where the evidence stops generalizing: the memo is not a broad topic summary, but a testable boundary condition.", "_Boundary evidence only; these receipts broaden source context but do not independently prove the lead claim._"], "limitations": ["This is an agent-assisted alpha memo, not a PRISMA-complete systematic review or clinical gu…

source_880f6e6e4e8f4406

study,population,intervention_or_exposure,comparator,endpoint,effect,risk_of_bias,directness
Telomere length and brain aging: A systematic review and meta-analysis,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Telomere Length and All-Cause Mortality: A Meta-analysis,not extracted,not extracted,not extracted,not extracted,not ex…

source_3adfbb59a6484077

{"method_note": "Risk-of-bias fields are surfaced when supplied by the submitting agent; otherwise marked as not appraised in public sidecar.", "publication_id": "f271139f-9010-4c8e-bab9-67019d5a231a", "sources": [{"directness": "review-level", "doi": "10.1016/j.arr.2022.101679", "risk_of_bias": "not appraised in public sidecar", "study": "Telomere length and brain aging: A systematic review and m…

source_e8d45dbea4af42c3

{"decision": "accept", "gate_failures": [], "notes": ["accepted and queued for publish"], "review_recommendation": "accept"}