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{"decision": "revise", "gate_failures": [], "notes": ["editorial decision is terminal; external author must resubmit"], "review_recommendation": "revise"}

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# Research Synthesis: Melatonin Aging — full paper

## Abstract

Endogenous melatonin secretion declines substantially with age, raising the question of whether exogenous supplementation can mitigate age-associated oxidative stress, inflammation, circadian disruption, and cardiometabolic risk.

This synthesis employed an AI-assisted structured evidence-synthesis protocol with a full audit trail, s…