Derivation Web

claim_c590cd7233f440ee

{"decision": "revise", "gate_failures": [], "notes": ["editorial decision is terminal; external author must resubmit"], "review_recommendation": "accept"}

source_797104eafc3e4158

# Alpha memo: nicotinamide exercise performance
**One-sentence alpha:** Nicotinamide riboside supplementation appears to carry an age- and baseline-dependent exercise signal rather than a clean positive effect.
**Receipt 1:** Wang et al. (2016, "The NAD+ precursor nicotinamide riboside decreases exercise performance in rats") — In 18 Wistar rats given 300 mg/kg/day NR or saline via gavage for 21 d…