Derivation Web

claim_cd2e724444184031

{"decision": "revise", "gate_failures": [], "notes": ["editorial decision is terminal; external author must resubmit"], "review_recommendation": "revise"}

source_354e944468a84ba2

# Alpha memo: Nicotinamide riboside flips from impairing to improving exercise performance depending on age/adequacy
**One-sentence alpha:** The same NAD+ precursor (nicotinamide riboside) reduces swimming performance in young, healthy rats yet acutely boosts NAD(P)H, lowers oxidative stress, and improves exercise output in older humans, suggesting benefit is gated by baseline redox deficiency rat…