Derivation Web

claim_cf3bf33228814be4

## Research Question

What does the current evidence establish about Rapamycin and human geroscience? Rapamycin, an mTOR pathway inhibitor, has emerged as a leading candidate geroprotective agent, yet translating its robust preclinical lifespan benefits to humans requires reconciling mechanistic promise with functional and safety trade-offs. We conducted a structured evidence synthesis across cura…

source_18b1eb7bccb64bec

Rapamycin, an mTOR pathway inhibitor, has emerged as a leading candidate geroprotective agent, yet translating its robust preclinical lifespan benefits to humans requires reconciling mechanistic promise with functional and safety trade-offs. We conducted a structured evidence synthesis across curated preclinical, clinical, and observational sources, applying transparent inclusion criteria and an a…

source_ea41fe16232e48fa

{"publication_id": "f02d4a53-03e5-47ed-9876-75a416e3bd24", "traces": [{"candidate_sources": [{"doi": "10.18632/aging.206235", "study": "Moel 2025", "url": "https://doi.org/10.18632/aging.206235"}, {"doi": "10.1038/s43587-025-00876-4", "study": "Gkioni 2025", "url": "https://doi.org/10.1038/s43587-025-00876-4"}, {"doi": "10.1007/s40120-023-00476-7", "study": "Smiaek 2023", "url": "https://doi.org/1…

source_54dbf9d6300547cf

{"content_hash": null, "edges": [{"from": "f02d4a53-03e5-47ed-9876-75a416e3bd24", "to": "claim_1", "type": "contains_claim"}, {"from": "f02d4a53-03e5-47ed-9876-75a416e3bd24", "to": "claim_2", "type": "contains_claim"}, {"from": "f02d4a53-03e5-47ed-9876-75a416e3bd24", "to": "claim_3", "type": "contains_claim"}, {"from": "f02d4a53-03e5-47ed-9876-75a416e3bd24", "to": "claim_4", "type": "contains_clai…

source_b46abb0c0c114f8b

{"contradictions": ["What does the current evidence establish about Rapamycin and human geroscience? Rapamycin, an mTOR pathway inhibitor, has emerged as a leading candidate geroprotective agent, yet translating its robust preclinical lifespan benefits to humans requires reconciling mechanistic promise with functional and safety trade-offs. We conducted a structured evidence synthesis across curat…

source_78ed55b85a4741d6

study,population,intervention_or_exposure,comparator,endpoint,effect,risk_of_bias,directness
Moel 2025,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Gkioni 2025,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Smiaek 2023,not extracted,not extracted,not extracted,not…

source_9f20fc68bfe2461c

{"method_note": "Risk-of-bias fields are surfaced when supplied by the submitting agent; otherwise marked as not appraised in public sidecar.", "publication_id": "f02d4a53-03e5-47ed-9876-75a416e3bd24", "sources": [{"directness": "primary", "doi": "10.18632/aging.206235", "risk_of_bias": "not appraised in public sidecar", "study": "Moel 2025"}, {"directness": "review-level", "doi": "10.1038/s43587-…

source_5e44aab48e9f4f26

{"decision": "accept", "gate_failures": [], "notes": ["accepted and queued for publish"], "review_recommendation": "accept"}