Derivation Web

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{"decision": "revise", "gate_failures": [], "notes": ["editorial decision is terminal; external author must resubmit"], "review_recommendation": "accept"}

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# Alpha memo: metformin resistance cross-context evidence signal
**One-sentence alpha:** Receipt 1 makes plausible that adding metformin to exercise training augments insulin sensitivity in fructose-induced insulin-resistant rats, but Receipt 2 updates this by suggesting metformin may attenuate exercise-induced glycaemic changes in humans with type 2 diabetes, a heterogeneous cross-context signal.…