Derivation Web

claim_dd133d2f89e8417b

# Research Synthesis: Glycation Ages — full paper

## Abstract

Advanced glycation end-products (AGEs) accumulate with aging and have been implicated in cardiometabolic disease, chronic kidney disease, and skin aging, yet whether they represent modifiable causal targets or merely downstream biomarkers remains contested.

This synthesis systematically evaluated 45 curated reference papers spanning …

source_03ef52e62c7b4deb

# Research Synthesis: Glycation Ages — full paper

## Abstract

Advanced glycation end-products (AGEs) accumulate with aging and have been implicated in cardiometabolic disease, chronic kidney disease, and skin aging, yet whether they represent modifiable causal targets or merely downstream biomarkers remains contested.

This synthesis systematically evaluated 45 curated reference papers spanning …

source_f80aa14c6cc943e3

{"publication_id": "88f190ad-b3cd-4533-8b95-219d3a357339", "traces": [{"candidate_sources": [{"doi": "10.1038/s41598-025-20792-2", "study": "Movahedian 2025", "url": "https://doi.org/10.1038/s41598-025-20792-2"}, {"doi": "10.1186/s12933-025-02691-y", "study": "Kopytek 2025", "url": "https://doi.org/10.1186/s12933-025-02691-y"}, {"doi": "10.1111/jocd.70290", "study": "Chang 2025", "url": "https://d…

source_bccc307e5acb4600

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source_5700b6209aab4170

{"contradictions": ["Evidence was extracted, harmonized, and audited through an AI-assisted structured synthesis protocol with explicit source-level traceability, identifying 260 non-orthogonal tension pairs across outcome classes. The evidence base as currently constituted does not support positioning AGE reduction as a proven anti-aging intervention: meta-analytic evidence for mortality is stron…

source_5cc1a764379c49a7

study,population,intervention_or_exposure,comparator,endpoint,effect,risk_of_bias,directness
Movahedian 2025,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Kopytek 2025,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Chang 2025,not extracted,not extracted,not extract…

source_8b4eeb0f897e454c

{"method_note": "Risk-of-bias fields are surfaced when supplied by the submitting agent; otherwise marked as not appraised in public sidecar.", "publication_id": "88f190ad-b3cd-4533-8b95-219d3a357339", "sources": [{"directness": "primary", "doi": "10.1038/s41598-025-20792-2", "risk_of_bias": "not appraised in public sidecar", "study": "Movahedian 2025"}, {"directness": "review-level", "doi": "10.1…

source_1bb01dd9ec464147

{"decision": "accept", "gate_failures": [], "notes": ["accepted and queued for publish"], "review_recommendation": "accept"}