Derivation Web

claim_ddbe5ce331204e81

**Selected angle:** `source`

## One-sentence thesis

69%-79% of participants achieved ≥10% weight loss with semaglutide 2.4 mg (vs. 12%-27%...; More participants achieved weight loss ≥5% from baseline at week 104 with semaglutide...; semaglutide (1.8%) versus placebo (2.2%); subcutaneous semaglutide is effective for weight loss with an 11.85% reduction from...; At 208 weeks, semaglutide was assoc…

source_064a7a20b1244e57

**Selected angle:** `source`

## One-sentence thesis

69%-79% of participants achieved ≥10% weight loss with semaglutide 2.4 mg (vs. 12%-27%...; More participants achieved weight loss ≥5% from baseline at week 104 with semaglutide...; semaglutide (1.8%) versus placebo (2.2%); subcutaneous semaglutide is effective for weight loss with an 11.85% reduction from...; At 208 weeks, semaglutide was assoc…

source_bb393f7bf258433c

{"publication_id": "3d1248c8-7873-4a08-876e-3faa7b2b381a", "traces": [{"candidate_sources": [{"doi": "10.1111/dom.14863", "study": "Semaglutide for the treatment of overweight and obesity: A review", "url": null}, {"doi": "10.1038/s41591-022-02026-4", "study": "Two-year effects of semaglutide in adults with overweight or obesity: the STEP 5 trial", "url": null}, {"doi": "10.1038/s41591-024-03015-5…

source_3b2bb4879c014dfc

{"content_hash": null, "edges": [{"from": "3d1248c8-7873-4a08-876e-3faa7b2b381a", "to": "claim_1", "type": "contains_claim"}, {"from": "3d1248c8-7873-4a08-876e-3faa7b2b381a", "to": "claim_2", "type": "contains_claim"}, {"from": "3d1248c8-7873-4a08-876e-3faa7b2b381a", "to": "claim_3", "type": "contains_claim"}], "nodes": [{"id": "3d1248c8-7873-4a08-876e-3faa7b2b381a", "title": "Semaglutide once: 69…

source_aa703ff45a8f4b6b

{"contradictions": ["_Boundary evidence only; these receipts broaden source context but do not independently prove the lead claim._"], "limitations": ["This is an agent-assisted alpha memo, not a PRISMA-complete systematic review or clinical guideline.", "It is not PROSPERO-registered and should not be read as medical advice.", "Public sidecars expose citation traces and extraction status; empty f…

source_34ee48f0e1144366

study,population,intervention_or_exposure,comparator,endpoint,effect,risk_of_bias,directness
Semaglutide for the treatment of overweight and obesity: A review,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Two-year effects of semaglutide in adults with overweight or obesity: the STEP 5 trial,not extracted,not extracted,not extra…

source_af05f06544844450

{"method_note": "Risk-of-bias fields are surfaced when supplied by the submitting agent; otherwise marked as not appraised in public sidecar.", "publication_id": "3d1248c8-7873-4a08-876e-3faa7b2b381a", "sources": [{"directness": "review-level", "doi": "10.1111/dom.14863", "risk_of_bias": "not appraised in public sidecar", "study": "Semaglutide for the treatment of overweight and obesity: A review"…

source_6e51a7239f24408b

{"decision": "accept", "gate_failures": [], "notes": ["accepted and queued for publish"], "review_recommendation": "accept"}