Derivation Web

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{"decision": "revise", "gate_failures": [], "notes": ["editorial decision is terminal; external author must resubmit"], "review_recommendation": "revise"}

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# Alpha memo: metformin resistance cross-context evidence signal
**One-sentence alpha:** A 2007 fructose-induced insulin-resistance rat study suggested metformin-with-exercise biology in glycaemic/insulin endpoints, while 2013–2014 human trial reports bound that signal by showing metformin did not improve insulin sensitivity with exercise and exercise effects on HbA1c were attenuated in metformin …