Derivation Web

claim_e3a94f04ec39426b

# Source literature boundary memo

## Research question

Across retrieved fact-level receipts for acarbose, which endpoints show directionally favorable versus null/non-convergent signals, and what matched PICO remains untested?

## Selection criteria

The source-literature fallback selected acarbose because the domain snapshot exposed enough fact-backed, topic-overlapping papers. The fallback req…

source_e086c1422e314e1d

# Source literature boundary memo

## Research question

Across retrieved fact-level receipts for acarbose, which endpoints show directionally favorable versus null/non-convergent signals, and what matched PICO remains untested?

## Selection criteria

The source-literature fallback selected acarbose because the domain snapshot exposed enough fact-backed, topic-overlapping papers. The fallback req…

source_67162dd81e544d0b

{"publication_id": "882d6167-8336-4714-87b4-501263f7898e", "traces": [{"candidate_sources": [{"doi": "10.1128/msphere.00528-18", "study": "The Glucoamylase Inhibitor Acarbose Has a Diet-Dependent and Reversible Effect on the Murine Gut Microbiome", "url": "https://doi.org/10.1128/msphere.00528-18"}, {"doi": "10.1371/journal.pone.0079697", "study": "Acarbose reduces blood glucose by activating miR-…

source_613003783fcf4b4b

{"content_hash": null, "edges": [{"from": "882d6167-8336-4714-87b4-501263f7898e", "to": "claim_1", "type": "contains_claim"}, {"from": "882d6167-8336-4714-87b4-501263f7898e", "to": "claim_2", "type": "contains_claim"}, {"from": "882d6167-8336-4714-87b4-501263f7898e", "to": "claim_3", "type": "contains_claim"}, {"from": "882d6167-8336-4714-87b4-501263f7898e", "to": "claim_4", "type": "contains_clai…

source_2c0fea8806734e65

{"contradictions": ["This receipt-backed scoping note has one bounded signal: acarbose shows context-dependent, not convergent, associations across this 5-source primary bundle (2013-2020). Grouped by direction, directionally favorable: 8-week treatment with acarbose significantly decreased fasting blood glucose; The mean HbA1c at week 24 was significantly decreased approximately 0.7% from baselin…

source_63a47c1067f64357

study,population,intervention_or_exposure,comparator,endpoint,effect,risk_of_bias,directness
The Glucoamylase Inhibitor Acarbose Has a Diet-Dependent and Reversible Effect on the Murine Gut Microbiome,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Acarbose reduces blood glucose by activating miR-10a-5p and miR-664 in diabetic rats.,n…

source_196d4257deb94bc5

{"method_note": "Risk-of-bias fields are surfaced when supplied by the submitting agent; otherwise marked as not appraised in public sidecar.", "publication_id": "882d6167-8336-4714-87b4-501263f7898e", "sources": [{"directness": "primary", "doi": "10.1128/msphere.00528-18", "risk_of_bias": "not appraised in public sidecar", "study": "The Glucoamylase Inhibitor Acarbose Has a Diet-Dependent and Rev…

source_677562fe009c4af7

{"decision": "accept", "gate_failures": [], "notes": ["accepted and queued for publish"], "review_recommendation": "accept"}