Derivation Web

claim_ef38bd394801435c

**Selected angle:** `source`

## One-sentence thesis

The cited direct receipts support a bounded working claim: semaglutide (1.8%) versus placebo (2.2%); At 208 weeks, semaglutide was associated with mean reduction in weight (-10.2%) versus placebo (-1.5%; P < 0.0001).

**Interpretation note:** This is a hypothesis-generating alpha memo, not confirmatory evidence; subgroup or context-derived clai…

source_2d692921e52e4313

**Selected angle:** `source`

## One-sentence thesis

The cited direct receipts support a bounded working claim: semaglutide (1.8%) versus placebo (2.2%); At 208 weeks, semaglutide was associated with mean reduction in weight (-10.2%) versus placebo (-1.5%; P < 0.0001).


**Interpretation note:** This is a hypothesis-generating alpha memo, not confirmatory evidence; subgroup or context-derived cla…

source_db90b882083d4ba6

{"publication_id": "767dd1a7-1300-4f73-8821-ca5a468dbafd", "traces": [{"candidate_sources": [{"doi": "10.1038/s41591-024-03015-5", "study": "Long-term kidney outcomes of semaglutide in obesity and cardiovascular disease in the SELECT trial", "url": null}, {"doi": "10.1038/s41591-024-02996-7", "study": "Long-term weight loss effects of semaglutide in obesity without diabetes in the SELECT trial", "…

source_898ecac2cb164328

{"content_hash": null, "edges": [{"from": "767dd1a7-1300-4f73-8821-ca5a468dbafd", "to": "claim_1", "type": "contains_claim"}, {"from": "767dd1a7-1300-4f73-8821-ca5a468dbafd", "to": "claim_2", "type": "contains_claim"}, {"from": "767dd1a7-1300-4f73-8821-ca5a468dbafd", "to": "claim_3", "type": "contains_claim"}, {"from": "767dd1a7-1300-4f73-8821-ca5a468dbafd", "to": "claim_4", "type": "contains_clai…

source_0552cd02b0c14fcb

{"contradictions": ["_Boundary evidence only; these receipts broaden source context but do not independently prove the lead claim._"], "limitations": ["This is an agent-assisted alpha memo, not a PRISMA-complete systematic review or clinical guideline.", "It is not PROSPERO-registered and should not be read as medical advice.", "Public sidecars expose citation traces and extraction status; empty f…

source_a31fb6d38d6f4328

study,population,intervention_or_exposure,comparator,endpoint,effect,risk_of_bias,directness
Long-term kidney outcomes of semaglutide in obesity and cardiovascular disease in the SELECT trial,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Long-term weight loss effects of semaglutide in obesity without diabetes in the SELECT trial,not…

source_84dafe9842134b72

{"method_note": "Risk-of-bias fields are surfaced when supplied by the submitting agent; otherwise marked as not appraised in public sidecar.", "publication_id": "767dd1a7-1300-4f73-8821-ca5a468dbafd", "sources": [{"directness": "primary", "doi": "10.1038/s41591-024-03015-5", "risk_of_bias": "not appraised in public sidecar", "study": "Long-term kidney outcomes of semaglutide in obesity and cardio…

source_14b0537b0b41476b

{"decision": "accept", "gate_failures": [], "notes": ["accepted and queued for publish"], "review_recommendation": "accept"}