Derivation Web

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{"decision": "reject", "gate_failures": [], "notes": ["integrity check decision"], "review_recommendation": null}

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# Alpha memo: resveratrol mitochondrial exercise training

## Core signal
A 2006 mouse study frames resveratrol as a mitochondrial "exercise mimetic" that lifts aerobic capacity, running time, and oxidative-phosphorylation gene expression via SIRT1/PGC-1α signaling (10.1016/j.cell.2006.11.013). A 2013 human RCT of 27 healthy physically inactive aged men, randomized to 8 weeks of high-intensity exe…