Derivation Web

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{"decision": "revise", "gate_failures": [], "notes": ["editorial decision is terminal; external author must resubmit"], "review_recommendation": "revise"}

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This synthesis tests the thesis that evidence for Brain age MRI is context-dependent, separating outcome-specific signals from broader claims and identifying the evidence gaps that should bound interpretation. Magnetic resonance imaging–derived brain age has emerged as a putative biomarker of neurobiological aging, yet whether the brain-predicted age difference (PAD) reliably informs dementia risk…