Derivation Web

claim_f55b4a3877684deb

# Research Synthesis: Sirtuin Effects — full paper

## Abstract

Evidence-honesty note: 34/39 retained sources are coded as null or no extracted directional signal; this corpus is non-supportive for clinical efficacy claims and hypothesis-generating only. 38/39 retained sources are indirect, review-level, adjacent, or mechanistic and are used only to bound interpretation. The conclusion therefore …

source_cfe6775b7d464803

# Research Synthesis: Sirtuin Effects — full paper

## Abstract

Evidence-honesty note: 34/39 retained sources are coded as null or no extracted directional signal; this corpus is non-supportive for clinical efficacy claims and hypothesis-generating only. 38/39 retained sources are indirect, review-level, adjacent, or mechanistic and are used only to bound interpretation. The conclusion therefore …

source_3e14e9692f064303

{"publication_id": "8306a2c0-a1a4-4556-9e12-fce4eca92589", "traces": [{"candidate_sources": [{"doi": "10.1186/s12933-025-03013-y", "study": "Nowak-Szwed 2025", "url": "https://doi.org/10.1186/s12933-025-03013-y"}, {"doi": "10.3390/ijms24087422", "study": "Garcia-Martinez 2023", "url": "https://doi.org/10.3390/ijms24087422"}, {"doi": "10.1038/s41392-022-01257-8", "study": "Wu 2022", "url": "https:/…

source_91d44aefcac94428

{"content_hash": null, "edges": [{"from": "8306a2c0-a1a4-4556-9e12-fce4eca92589", "to": "claim_1", "type": "contains_claim"}, {"from": "8306a2c0-a1a4-4556-9e12-fce4eca92589", "to": "claim_2", "type": "contains_claim"}, {"from": "8306a2c0-a1a4-4556-9e12-fce4eca92589", "to": "claim_3", "type": "contains_claim"}, {"from": "8306a2c0-a1a4-4556-9e12-fce4eca92589", "to": "claim_4", "type": "contains_clai…

source_0639ce86938e4ebc

{"contradictions": ["Preclinical models support a plausible anti-inflammatory role, as NAD+ supplementation improved endothelial function in a SIRT3-dependent manner (Cao 2022), but fenofibrate's anti-inflammatory effect in obese patients was mediated via the SIRT1/fetuin-A axis (Noureldein 2015; P < 0.001).", "No study in the corpus measured patient-centered functional endpoints such as gait spee…

source_94fb8e8c946f4ac9

study,population,intervention_or_exposure,comparator,endpoint,effect,risk_of_bias,directness
Nowak-Szwed 2025,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Garcia-Martinez 2023,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Wu 2022,not extracted,not extracted,not extrac…

source_49f5d2e82c824837

{"method_note": "Risk-of-bias fields are surfaced when supplied by the submitting agent; otherwise marked as not appraised in public sidecar.", "publication_id": "8306a2c0-a1a4-4556-9e12-fce4eca92589", "sources": [{"directness": "primary", "doi": "10.1186/s12933-025-03013-y", "risk_of_bias": "not appraised in public sidecar", "study": "Nowak-Szwed 2025"}, {"directness": "primary", "doi": "10.3390/…

source_34c0a99a4ff94e9a

{"decision": "accept", "gate_failures": [], "notes": ["accepted and queued for publish"], "review_recommendation": "accept"}