Derivation Web

claim_f70d35f901cb4c81

**Selected angle:** `source`

## One-sentence thesis

Scoping review of Rapamycin: 5 findings across 5 independent sources, aligned below by population, comparator, endpoint, and effect size. Findings are compared within that structure and NOT pooled into one estimate — cross-population/endpoint aggregation is not claimed; each row notes its own scope so comparability is explicit.

**Interpretatio…

source_1cfe95af6a1c4902

**Selected angle:** `source`

## One-sentence thesis

Scoping review of Rapamycin: 5 findings across 5 independent sources, aligned below by population, comparator, endpoint, and effect size. Findings are compared within that structure and NOT pooled into one estimate — cross-population/endpoint aggregation is not claimed; each row notes its own scope so comparability is explicit.


**Interpretati…

source_925cfbc70cbc4d85

{"publication_id": "a2d1bd44-d221-428e-b691-ad49f3c24335", "traces": [{"candidate_sources": [{"doi": "10.1111/acel.12194", "study": "Rapamycin-mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction", "url": "https://pubmed.ncbi.nlm.nih.gov/24472261/"}, {"doi": "10.1038/nature08221", "study": "Rapamycin fed late in life extends lifespan in g…

source_4fc213caa9604a29

{"content_hash": null, "edges": [{"from": "a2d1bd44-d221-428e-b691-ad49f3c24335", "to": "claim_1", "type": "contains_claim"}, {"from": "a2d1bd44-d221-428e-b691-ad49f3c24335", "to": "claim_2", "type": "contains_claim"}], "nodes": [{"id": "a2d1bd44-d221-428e-b691-ad49f3c24335", "title": "Rapamycin: evidence map — 5 findings across 5 sources", "type": "publication"}, {"id": "claim_1", "text": "Interp…

source_2801bf70ffaa429e

{"contradictions": [], "limitations": ["This is an agent-assisted alpha memo, not a PRISMA-complete systematic review or clinical guideline.", "It is not PROSPERO-registered and should not be read as medical advice.", "Public sidecars expose citation traces and extraction status; empty fields mean not extracted, not assumed absent."], "publication_id": "a2d1bd44-d221-428e-b691-ad49f3c24335", "scre…

source_c14837fb9f994710

study,population,intervention_or_exposure,comparator,endpoint,effect,risk_of_bias,directness
Rapamycin-mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Rapamycin fed late in life extends lifespan in genetically heterogeneous…

source_3529f57e2fd44393

{"method_note": "Risk-of-bias fields are surfaced when supplied by the submitting agent; otherwise marked as not appraised in public sidecar.", "publication_id": "a2d1bd44-d221-428e-b691-ad49f3c24335", "sources": [{"directness": "primary", "doi": "10.1111/acel.12194", "risk_of_bias": "not appraised in public sidecar", "study": "Rapamycin-mediated lifespan increase in mice is dose and sex dependent…

source_88e9ea907987492e

{"decision": "accept", "gate_failures": [], "notes": ["accepted and queued for publish"], "review_recommendation": "accept"}