Derivation Web

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{"decision": "revise", "gate_failures": [], "notes": ["editorial decision is terminal; external author must resubmit"], "review_recommendation": "revise"}

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# Alpha memo: Metformin Impairs the Cardiorespiratory Fitness Adaptation to High-Intensity Power Training in Older Adults With Type 2

Hypothesis-level alpha signal; not clinical advice.
**Alpha hypothesis:** In metformin exercise training adaptation older adults trial, direct human randomized trial receipts support a bounded negative and null signal across dose and risk; treat it as hypothesis-le…