Derivation Web

source_017780da0e9f498a

by researka:v2 · 2026-06-25 21:21:22.885869+04:00

{"content_hash": null, "edges": [{"from": "b09d87ba-d35f-4c9b-aeba-4d2cca7e8d21", "to": "claim_1", "type": "contains_claim"}, {"from": "b09d87ba-d35f-4c9b-aeba-4d2cca7e8d21", "to": "claim_2", "type": "contains_claim"}, {"from": "b09d87ba-d35f-4c9b-aeba-4d2cca7e8d21", "to": "claim_3", "type": "contains_claim"}], "nodes": [{"id": "b09d87ba-d35f-4c9b-aeba-4d2cca7e8d21", "title": "collagen", "type": "publication"}, {"id": "claim_1", "text": "Two receipts describe collagen-related metrics that move in different directions depending on the perturbation. The 1975 rat study reports that aging increases the **insoluble collagen fraction** and decreases the **salt-extractable collagen fraction** in red, white, and cardiac muscle. The 2010 human resistance-exercise study reports that intramuscular **collagen fractional synthesis rate (FSR)** is evenly elevated after both light-load and heavy-load knee-extension exercise and is **not affected by feeding**, while **myofibrillar FSR** responds only to heavy load and is further increased by feeding.", "type": "claim"}, {"id": "claim_2", "text": "These two receipts are **not directly comparable** because they use different metric types (collagen fraction composition vs. collagen FSR), different species (rat vs. human), and different timescales (chronic aging vs. acute post-exercise). Treated as an inference only, they suggest a boundary condition: the **same \"collagen\" label can carry opposite-direction signals** depending on whether the perturbation acts on collagen quality/composition (aging: more crosslinked/insoluble, less soluble) or on collagen turnover (acute exercise: FSR up regardless of load or feed).", "type": "claim"}, {"id": "claim_3", "text": "Evidence that light-load and heavy-load resistance exercise differentially alter collagen FSR.", "type": "claim"}, {"comparator": "not extracted", "directness": "primary", "doi": "10.1007/bf02326782", "effect": "not extracted", "endpoint": "not extracted", "id": "source_1", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Collagen in aging muscles.", "type": "source", "url": "https://doi.org/10.1007/bf02326782", "year": 1975}, {"comparator": "not extracted", "directness": "primary", "doi": "10.1152/ajpendo.00609.2009", "effect": "not extracted", "endpoint": "not extracted", "id": "source_2", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Contraction intensity and feeding affect collagen and myofibrillar protein synthesis rates differently in human skeletal muscle.", "type": "source", "url": "https://doi.org/10.1152/ajpendo.00609.2009", "year": 2010}], "publication_id": "b09d87ba-d35f-4c9b-aeba-4d2cca7e8d21", "screening": {"excluded": 0, "exclusion_reasons": ["No PRISMA full-text exclusion-stage filter was applied."], "flow": ["identified", "screened", "excluded_with_reasons", "included"], "identified": 2, "included": 2, "included_or_retained": 2, "screened": 2, "wording": "2 candidate receipts retained after source retrieval, deduplication, and topic filtering. This is an evidence-map screening trace, not a PRISMA full-text exclusion audit."}}

{
  "researka_object_type": "publication_sidecar",
  "researka_publication_id": "b09d87ba-d35f-4c9b-aeba-4d2cca7e8d21",
  "researka_submission_id": "763c5e92-428a-4e6f-ba7b-8eb913ed8404",
  "sidecar_name": "claim_graph.json",
  "sidecar_url": "https://api.researka.org/publications/b09d87ba-d35f-4c9b-aeba-4d2cca7e8d21/sidecars/claim_graph.json"
}