Derivation Web

source_01bdda8ac57f4b29

by researka:v2 · 2026-06-22 08:30:13.590747+04:00

study,population,intervention_or_exposure,comparator,endpoint,effect,risk_of_bias,directness
GDF11 slows excitatory neuronal senescence and brain ageing by repressing p21,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Dietary intake of GDF11 delays the onset of several biomarkers of aging in male mice through anti-oxidant system via Smad2/3 pathway,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Activated GDF11/8 subforms predict cardiovascular events and mortality in humans,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Systemic GDF11 attenuates depression-like phenotype in aged mice via stimulation of neuronal autophagy,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Acute endurance exercise modulates growth differentiation factor 11 in cerebrospinal fluid of healthy young adults,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Protogenin facilitates trunk-to-tail HOX code transition via modulating GDF11/SMAD2 signaling in mammalian embryos,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Loss of Growth Differentiation Factor 11 Shortens Telomere Length by Downregulating Telomerase Activity,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"MeCP2 regulates Gdf11 , a dosage-sensitive gene critical for neurological function",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
GDF11-secreting cell transplant efficiently ameliorates age-related pulmonary fibrosis,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Myogenic differentiation of human myoblasts and Mesenchymal stromal cells under GDF11 on Poly-ɛ-caprolactone-collagen I-Polyethylene-nanofibers,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Exogenous GDF11, but not GDF8, reduces body weight and improves glucose homeostasis in mice",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Circulating GDF11 exacerbates myocardial injury in mice and associates with increased infarct size in humans,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
GDF11 inhibits adipogenesis and improves mature adipocytes metabolic function via WNT/β‐catenin and ALK5/SMAD2/3 pathways,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
GDF11 alleviates glucocorticoid-induced osteonecrosis of the femoral head by regulating angiogenesis via the PI3K-AKT-eNOS pathway,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
GDF11 induces mild hepatic fibrosis independent of metabolic health,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Growth differentiation factor 11 attenuates cardiac ischemia reperfusion injury via enhancing mitochondrial biogenesis and telomerase activity,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Elevated circulating GDF11 and its role in age-related sarcopenia: insights from clinical, transcriptomic, and in vitro analyses",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
GDF11 protects against mitochondrial-dysfunction-dependent NLRP3 inflammasome activation to attenuate osteoarthritis,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Growth differentiation factor 11 attenuates liver fibrosis via expansion of liver progenitor cells,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"GDF11 promotes osteogenesis as opposed to MSTN, and follistatin, a MSTN/GDF11 inhibitor, increases muscle mass but weakens bone",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Investigating and correcting a rare pathogenic mutation in GDF11,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Hapln1 promotes dedifferentiation and proliferation of iPSC-derived cardiomyocytes by promoting versican-based GDF11 trapping,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Longitudinal Relationship Between Growth Differentiation Factor 11 and Physical Activity in Chronic Obstructive Pulmonary Disease,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Evaluation of potential aging biomarkers in healthy individuals: telomerase, AGEs, GDF11/15, sirtuin 1, NAD+, NLRP3, DNA/RNA damage, and klotho",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Growth differentiation factor 11 accelerates liver senescence through the inhibition of autophagy,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"A systems approach using Diversity Outbred mice distinguishes the cardiovascular effects and genetics of circulating GDF11 from those of its homolog, myostatin",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Heterozygous loss-of-function variants significantly expand the phenotypes associated with loss of GDF11,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
GDF11 inhibits the malignant progression of hepatocellular carcinoma via regulation of the mTORC1‑autophagy axis,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Association of a variant upstream of growth differentiation factor 11 ( GDF11 ) on carcass traits in crossbred beef cattle,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Endogenous GDF11 regulates odontogenic differentiation of dental pulp stem cells,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Exosome-transmitted miR-3124-5p promotes cholangiocarcinoma development via targeting GDF11,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
PPAR α Targeting GDF11 Inhibits Vascular Endothelial Cell Senescence in an Atherosclerosis Model,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Bioinformatics network analyses of growth differentiation factor 11,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Novel insights into the pleiotropic health effects of growth differentiation factor 11 gained from genome-wide association studies in population biobanks,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
GDF11 inhibits adipogenesis of human adipose-derived stromal cells through ALK5/KLF15/β-catenin/PPARγ cascade,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Expression profiling by high-throughput sequencing reveals GADD45, SMAD7, EGR-1 and HOXA3 activation in Myostatin (MSTN) and GDF11 treated myoblasts",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Anti-Aging Effects of GDF11 on Skin,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Similar sequences but dissimilar biological functions of GDF11 and myostatin,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"A GDF11/myostatin inhibitor, GDF11 propeptide-Fc, increases skeletal muscle mass and improves muscle strength in dystrophic mdx mice",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Circulating GDF11 levels are decreased with age but are unchanged with obesity and type 2 diabetes,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Systemic GDF11 stimulates the secretion of adiponectin and induces a calorie restriction‐like phenotype in aged mice,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Gdf11 gene transfer prevents high fat diet-induced obesity and improves metabolic homeostasis in obese and STZ-induced diabetic mice,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Lifelong exercise, but not short‐term high‐intensity interval training, increases GDF 11, a marker of successful aging: a preliminary investigation",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
GDF11 upregulation independently predicts shorter overall-survival of uveal melanoma,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Growth differentiation factor 11 (GDF11) has pronounced effects on skin biology,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Growth differentiation factor 11 inhibits adipogenic differentiation by activating TGF‐beta/Smad signalling pathway,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Role of growth differentiation factor 11 in development, physiology and disease",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
GDF11 Does Not Rescue Aging-Related Pathological Hypertrophy,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
"**Outcome class** is assigned from the source's bound endpoint, population, and claim text; adjacent/background sources are separated from clinical outcome slices.",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
"**Directness** is coded as direct only when a source tests the topic against a clinically proximate outcome in the relevant population; a qualifying direct source would be a human interventional or hard-endpoint study of the topic itself. Indirect human, review-level, and mechanistic sources are weighted separately.",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
"**Directional signal** is counted within the assigned outcome class only. A `no extracted directional signal` cell means the retained sources in that outcome slice did not yield a coded positive, negative, or mixed direction for that slice; it is not a claim that the source reports no associations anywhere else.",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
**Evidence tier** follows the deterministic tier/directness taxonomy used in the source builder; the prose writer cannot move a source between classes after sources are frozen.,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
Studenski 2011,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
Perera 2006,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
ADA 2024,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
WHO 2000,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
Cruz-Jentoft 2019,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation

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