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# Alpha memo: metformin resistance cross-context evidence signal **One-sentence alpha:** Animal work supports a biological premise for metformin combined with endurance-style training, whereas clinical data suggest that, in adults with type 2 diabetes, metformin does not add to the glycaemic benefit of aerobic, resistance, or combined training and may attenuate exercise-induced glycaemic gains. **…
sha256 3301250ef323e3d3…