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{"contradictions": ["Preclinical models support a plausible anti-inflammatory role, as NAD+ supplementation improved endothelial function in a SIRT3-dependent manner (Cao 2022), but fenofibrate's anti-inflammatory effect in obese patients was mediated via the SIRT1/fetuin-A axis (Noureldein 2015; P < 0.001).", "No study in the corpus measured patient-centered functional endpoints such as gait spee…
sha256 060b51ef160e2cd0…